What Is ALS?
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that affects the motor neurons in the brain and spinal cord. These neurons control muscle movement, and as they die, muscles weaken, shrink, and eventually lose function.
Common Symptoms of ALS
ALS often begins subtly, with signs that can be mistaken for normal aging or minor injury:
Muscle twitches (fasciculations)
- Weakness in arms, legs, or hands
- Slurred speech or difficulty swallowing
- Trouble with balance or walking
- Progressive loss of strength
As ALS advances, it can impair breathing and mobility, requiring assistive devices or ventilatory support.
What Causes ALS?
The exact cause remains unknown, but genetic and environmental factors both contribute.
- Genetic mutations: C9orf72, SOD1, TARDBP, FUS are common genetic drivers.
- Protein misfolding: Abnormal proteins like TDP-43 accumulate in neurons.
- Neuroinflammation and oxidative stress: Play a key role in nerve degeneration.
- Environmental exposures: Toxins, military service, or trauma may increase risk.
Is ALS Fatal?
ALS is life-limiting, with an average survival of 3–5 years after diagnosis. However, with modern care, many patients live longer and maintain independence for years.
Treatment Options for ALS
ALS has no cure, but treatments can slow progression and improve quality of life.
1. FDA-approved therapies
- Riluzole: modestly extends survival by reducing glutamate toxicity.
- Edaravone: antioxidant therapy that slows functional decline.
2. Supportive interventions
- Physical, speech, and occupational therapy
- Non-invasive ventilation to support breathing
- Nutritional support (feeding tubes if needed)
3. Advanced research therapies
- Antisense oligonucleotides (ASOs): Target faulty genes like SOD1 and C9orf72.
- Stem cell and gene therapy trials: Aimed at protecting or repairing neurons.
- Biomarker-driven approaches: Identifying early inflammation and oxidative stress for targeted intervention.
ALS Care at Premier Neuro Health
At Premier Neuro Health, ALS care combines scientific precision with compassionate support.
Dr. Souayah has published research on nerve conduction slowing, oxidative stress, and ALS biomarkers.
This integration of laboratory insight and clinical expertise allows earlier detection, personalized interventions, and optimized quality of life.
Take Action Early
ALS remains a challenging diagnosis, but research is advancing rapidly. With timely evaluation, FDA-approved drugs, multidisciplinary support, and access to clinical trials, patients can preserve function and find meaningful hope.
If you or a loved one notice unexplained muscle weakness, twitching, or slurred speech, schedule an appointment for a Comprehensive ALS Evaluation at Premier NeuroHealth today.
